Drug induced nephrotoxicity analysis in hiv therapy. Original article does intraperitoneal medical ozone. Lead acetate induced nephrotoxicity in wistar albino rats. It causes almost 10% of intellectual disability of otherwise unknown cause and can result in behavioral problems. Department of pharmaceutical sciences jjtu page 10. Clinical pharmacology for the nephrologist khaled eldahshan, md lecturer of nephrology, mansoura urology and nephrology center. Nephrotoxicity is a complication due to the effect of some toxic chemicals on kidneys. Effect of cimetidine on gentamicinlosartan induced. The late sequelae of chronic lead exposure remain the subject of continuing controversy.
Prediction of druginduced nephrotoxicity and injury. At lower levels of lead exposure such as drinking water, the effect on kidney function takes years of exposure 5 to 30 years and should be modest. White lead is one of the oldest of artificial pigments. Drug induced nephrotoxicity can lead to acute kidney injury aki or chronic kidney disease in patients and is a major problem for clinicians 2,3.
More side effects increased nephrotoxicity change in the drug metabolism 4. This study aimed to investigate the potential effects of berberis vulgaris l. The aim of the present study is to clarify the possible corrective role of curcumin on the nephrotoxicity induced by lead acetate. Gentamicin gm induced nephrotoxicity limits its longterm clinical use.
Introduction gentamicin is an aminoglycoside antibiotic widely used for the treatment of bacterial infections. In this study, we investigated the protective effects of piperine on lead acetateinduced renal damage in rat kidney tissue. Sabah ansar 1, sarah farhat2, aljohara am albati 3, manal abudawood 1, sherifa hamed4 1clinical laboratory sciences, applied medical sciences, king saud university, saudi arabia 2lawrence high, lawrence, kansas, usa 3clinical health sciences, applied medical sciences, king saud university, saudi arabia. Maternal blood lead, from exogenous and endogenous sources, can cross the placenta and pose a.
Version 2020 of the acr manual on contrast media was published in january 2020 as a webbased product. What are possible health effects from lead exposure. Original article serum metabonomic analysis of rats with cisplatin induced nephrotoxicity and panax notoginseng saponins treatment yue qiu, yufang yang, zhenguang huang, xiaoqin zou, jinling zhou, xinwen liu department of pharmacy, the first affiliated hospital of guangxi medical university, nanning, guangxi, peoples republic of china. A study was carried out to check for the nephroprotective action. Role of ampk pathway in leadinduced endoplasmic reticulum. Low socioeconomic status is a risk factor for both lead exposure and diseases that increase susceptibility. However, data are currently too limited to merit in depth discussion. Moreover, great at tention should be paid to drug interactions. Such areas include the potential for lead related nephrotoxicity in children, genetic susceptibility, and coexposures, of which cadmium is the most important. Protective role of hydroalcoholic extract of ficus carica.
Current study planned to screen the effect of coriander and fennel aqueous seeds extracts on lead induced nephrotoxicity. Pertinent earlier papers from the investigators files were discussed. Several agentsstrategies were attempted to prevent gm nephrotoxicity but were not found suitable for clinical practice. In comparison, the health impacts of chronic lowlevel exposure to cd and pb. Many patients who develop renal injury after drug exposure have identifiable risk factors that could be modified or that should preclude the use of these drugs in the first place.
Original article nephroprotective effect of low viscosity. Efficacy of curcumin on lead induced nephrotoxicity in. Biochemical evidence for lead and mercury induced transbilayer movement of phospholipids mediated by human phospholipid scramblase 1. D glucosaminase nag activity in urine, creatinine clearance, oxidative stress tbars and gsh parameters and histopathological changes in the kidney. Mice were exposed chronically to lead acetate, at a dose of 5 mgkg, alone or in conjunction with b. Oxidative stress plays a key role in lead induced nephrotoxicity. Toxicology letters, 46 1989 153162 153 txl 02127 mechanisms of lead and cadmium nephrotoxicity r. Protective effects of piperine on lead acetate inducednephrotoxicity. Study of protective effects of stem bark extracts of ficus racemosa in drug induced nephrogenic diabetes insipidus and nephrotoxicity in animal models. Symptoms may include abdominal pain, constipation, headaches, irritability, memory problems, inability to have children, and tingling in the hands and feet. Protective effect of hydroalcoholic extract of lavandula.
Finally, determination of a patients or donors genotype of drugmetabolizing genes or of mol ecules involved in csa nephrotoxicity. The content on the uptodate website is not intended nor recommended as. Pertinent earlier papers from the investigators files were discussed when. Lead poisoned children who are not chelated are at increased risk for nephropathy as young adults. Patients with multiple risk factors are particularly at risk for vancomycin induced nephrotoxicity. Efficacy of astragalin on lead acetate induced nephrotoxicity in male albino rats. Evidence suggests an association between lead exposure and certain reproductive and developmental outcomes. The protective effects of dmsa and some vitamins against.
Based on the study, it can be stated that lead induced nephrotoxicity particularly damages the. Pdf efficacy of astragalin on lead acetate induced. Despite dramatic improvements in patient survival and drug tolerability, nephrotoxicity remains an important complication of chemotherapy. With acute lead nephrotoxicity, these leadprotein complexes are observed as typical intracellular inclusions. Request pdf lead acetate induced nephrotoxicity in wistar albino rats.
Histological results showed that gentamicin could lead to kidney damage and tubular necrosis. Erythrophagocytosis of leadexposed erythrocytes by renal. Treatment of acute lead nephropathy in children appears to prevent the. Nephrotoxicity of vancomycin and aminoglycoside therapy separately and in combination.
Most lead related kidney disease is found in people who work in jobs where they are exposed to very high levels of lead. The association between lead exposure and nephrotoxicity has been. Lead poisoning and associated nephrotoxicity is an important and preventable health problem that remains to be fully addressed. The risk is incremental with higher trough levels and longer duration of therapy. Radiocontrast media induced nephrotoxicity is thought to result from direct tubular toxicity and renal ischemia.
Lead pb toxicity remains a significant public health problem because of its global pervasiveness and its adverse effects on the renal system. Cadmium and lead are divalent cations with a propensity to settle in the proximal tubule of the nephron, leading to nephrotoxicity. These agents are freely filtered by the glomeruli and quickly taken up by the proximal tubular epithelial cells, where they are incorporated into lysosomes after first interacting with phospholipids on the brush border membranes. Druginduced nephrotoxicity analysis in hiv therapy. Lead exposure and kidney function national kidney foundation. Nephrotoxins are chemicals displaying nephrotoxicity. Patients at highest risk of druginduced nephrotoxicity are those with one or more of the following.
The pathophysiological results, however, tend to diverge. Lead poisoning is a type of metal poisoning caused by lead in the body. Acute nephrotoxicity consists of proximal tubular dysfunction and can be reversed by treatment with chelating agents. Seventytwo adult male rats were equally divided to 6 groups. Pdf how to prevent, recognize, and treat druginduced. Full text druginduced impairment of renal function ijnrd. Drugs can also interfere with normal transport mechanisms in the.
However due to lack of education regarding the dangers of working with lead or lead containing products, potential health hazards of lead poisoning still exist. Hydroalcohalic extract of ficus carica hefc retard the progression of certain types of cancers, cardiovascular and renal disorders. Chronic nephropathy is one of the oldest recognized health effects of lead. Human exposure is mainly via food and water, with some via air, dust and soil. Effect of curcumin and curcumin nanoparticles against lead induced nephrotoxicity. Content changes may take place as a result of changes in technology, clinical treatment, or other evidence ba sed. Neither sir george baker nor tanguerel des planches, the major contributors to knowledge of lead toxicity in the eighteenth and nineteenth centuries, noted that renal disease or gout were complications of chronic lead. Nephroprotective effect of costus afer on lead induced kidney. Amelioration of leadinduced toxicity in blood, liver and kidney tissues of male wistar rats by fermented ofada rice eferhire aganbi 1, oghenetega jonathan avwioroko 2, emm anuel rex enabulele 1. Future public health risk for leadrelated nephrotoxicity may be most significant in those rapidly developing countries where risk factors for ckd, including obesity and secondary htn and diabetes mellitus. Does intraperitoneal medical ozone preconditioning and treatment ameliorate the methotrexate induced nephrotoxicity in rats.
Nephrotoxicity and agents responsible nephrotoxic injury is damage to one or both kidenys that result from exposure to a toxic substance. This study aimed to acquire the concentration of vancomycin in the renal tubules and kidneys in humans using physiologically based pharmacokinetic pbpk modeling and simulation. Drug induced nephrotoxicity is one of the leading causes of aki worldwide. Increased oxidative stress and upregulation of nephrotoxic biomarkers. Cimetidine appears to have protective effect on gentamicinlosartan induced nephrotoxicity in rats. Lead nephropathy and leadrelated nephrotoxicity uptodate. Cadmium and lead are two of the most prevalent as well as two of the most nephrotoxic metals known to man. With the prohibitive cost and unavailability of metal chelators, chronic kidney disease ckd prevention is very difficult hence the search for.
Download printerfriendly version adobe pdf file adobe pdf file. Abatement and mitigation 3 jersey zinc company, in a 1906 advertisement, observed that. Low socioeconomic status is a risk factor for both lead exposure and. Leadinduced chronic renal failuredefinitionlead pb nephrotoxicity relates to experimental, epidemiologic, and clinical evidence of renal damage and hypertension associated to environmental or occupational pb exposure. Original article serum metabonomic analysis of rats with. Leadinduced nephrotoxicity was assessed in terms of decrease in urine volume, blood urea nitrogen bun, serum creatinine, proteinuria, glomerular filtration rate gfr, n acetyl.
Onconephrology is a new area that is rapidly expanding and requires a close working relationship between oncologists and nephrologists. Environmental exposure to moderatetohigh levels of cadmium cd and lead pb is associated with nephrotoxicity. Lead occurs primarily in the inorganic form in the environment. In addition to causing aki, chronic drug toxicity can, in some cases, lead to ckd and eventual endstage renal disease. Lead exposure may lead to increased risk for hypertension and its sequelae. A pathological, immunohistochemical and ultrasructural studies lead is a long known poison of environment and. Effect of curcumin and curcumin nanoparticles against lead. Dosedependent effect of coriander coriandrum sativum l. Chronic lead nephrotoxicity consists of interstitial fibrosis and progressive nephron loss, azotaemia and renal failure. The normal gbhp is 55mm hg, which favors the filtration. Scientific opinion on lead in food 2010 efsa journal. Outline the potential for methoxyflurane and sevo to produce toxic effects on the kidney.
Nephrotoxicity results from lead exposure because the kidney is the main route by which lead is eliminated. The high level of lead exposure required to cause lead nephropathy is now increasingly rare, particularly in developed countries, due to occupational controls and removal of lead from paint, gasoline, and other environmental sources figure 1. Maternal blood lead, from exogenous and endogenous sources, can cross the placenta and pose a risk to the fetus. Pdf a comparison of the nephrotoxicity of low doses of. In average adult consumers, lead dietary exposure ranges from 0. The results showed that hydroalcoholic extract of lavandula officinalis reduces biochemical indices and oxidative stress parameters against gentamicin induced nephrotoxicity icity. As of today we have 78,789,783 ebooks for you to download for free. Environmental health perspectives 2015, 123 2, 120127. Lead is absorbed by the proximal tubular cells of the renal tubules, where it binds to specific leadbinding proteins. The prevention of renal diseases induced by exposure to industrial or environmental pb largely relies on the capability to detect nephrotoxic effects at a stage when they are still reversible or at least not yet compromising the renal function. Pdf lead induced nephrotoxicity with special reference to. Role of ampk pathway in lead induced endoplasmic reticulum stress in kidney and in paeonol induced protection in mice. Goyer department of pathology, university of western ontario, london, ontario, n6a 5c1 canada summary exposure to lead results in accumulation in proximal renal tubular lining cells in the form of mor phologically discernible inclusion bodies which are lead protein complexes.
Of independent risk factors amikacin or cyclosporine treatment, mean daily. Gentamicin, cimetidine, losartan, vitamin e, rats, nephrotoxicity. Pharmacodynamics both agents with lead to vrenal blood flow o vgfrvuo o potential for worsening renal failure if pt not adequately prehydrated methoxyflurane is highly soluble. Renal effects of environmental and occupational lead exposure. Aminoglycosides preferentially affect the proximal tubular cells. Mechanisms of lead and cadmium nephrotoxicity sciencedirect. Chronic lead exposure can affect a variety of organ systems, including the kidney, where it can produce lead nephropathy, a chronic interstitial nephritis. It is, first of all, a cumulative poison, and the prevalence of lead colic among painters and lead workers has induced restrictive legislation in many. Pdf lead pollution is one of the most important problems of environmental and occupational origin.
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